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Free News Articles Home Drugs and Pharmaceuticals ASCO 2008: Tumor-Targeted Rexin-G Demonstrates Dose-Dependent Anti-Tumor Activity without Toxicity in Metastatic Pancreatic Cancer ASCO 2008: Tumor-Targeted Rexin-G Demonstrates Dose-Dependent Anti-Tumor Activity without Toxicity in Metastatic Pancreatic Cancer Author: Epeius Biotechnologies Corporation
Dateline: Mon Cheap Frank Kaminsky Shirt , 19 May 2008

freeNewsArticles Story Summary: “SAN MARINO, Calif., May 19 (SEND2PRESS NEWSWIRE) -- Epeius Biotechnologies announced today the results of an on-going Phase III study of Rexin-G for metastatic pancreatic cancer (Chawla et al., ASCO meeting, 2008). Continuing on with the planned dose-escalations of Rexin-G which began in 2005 using lower doses of Rexin-G in a Phase I safety study (Molecular Therapy Cheap Cody Zeller Shirt , 2008), the current Phase III study employed higher dose-escalations of Rexin-G given i.v. two to three times a week for 4 weeks.”

A R T I C L E:

SAN MARINO, Calif., May 19 (SEND2PRESS NEWSWIRE) -- Epeius Biotechnologies announced today the results of an on-going Phase III study of Rexin-G for metastatic pancreatic cancer (Chawla et al., ASCO meeting Cheap Michael Kidd-Gilchrist Shirt , 2008). Continuing on with the planned dose-escalations of Rexin-G which began in 2005 using lower doses of Rexin-G in a Phase I safety study (Molecular Therapy, 2008), the current Phase III study employed higher dose-escalations of Rexin-G given i.v. two to three times a week for 4 weeks, beginning with 8 x 10e11 cfu to 6 x 10e12 cfu with a goal to safely reach the point where the clinical anti-tumor activity of Rexin-G would be clearly and unequivocally demonstrated.

The results of this latest Phase III study of targeted gene delivery in vivo are very encouraging-intravenous infusions of Rexin-G demonstrated significant biological activity without toxicity in patients with progressive chemo-resistant pancreatic cancer. Once the overall safety record of repeated infusions of Rexin-G was clearly demonstrated, the FDA approved across the board intra-patient dose-escalations (an adaptive design) to gain better tumor control.

These higher doses of Rexin-G were associated with stabilization of disease Cheap Dwight Howard Shirt , using both RECIST and International PET criteria, significant reductions in CA 19.9 levels, and an increase in median overall survival (greater than 6 months) which was twice that observed in the low-dose safety study. No dose-limiting toxicity was observed, even at these higher doses of Rexin-G, thus confirming that repeated infusions of Rexin-G are safe and well-tolerated.

The importance of these progressive dose-escalation studies - which clearly establish safety before escalating to more potent tumoricidal levels - is of primary concern in the development of a new genetic medicine like Rexin-G. Moreover Cheap Michael Carter-Williams Shirt , the establishment of a functional dose-response relationship is also of fundamental significance, not o. Fake NBA Jerseys From China Cheap Fake Hockey Jerseys Fake Football Jerseys Free Shipping Fake College Jerseys Free Shipping Cheap Fake Jerseys Shop Cheap Fake Basketball Jerseys Replica Cheap Fake Baseball Jerseys Replica Cheap Fake Jerseys Replica Cheap Fake Jerseys Free Shipping Zach Ertz Eagles Jersey